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UK: Cannabis effective at relieving pain after major surgery

News-Medical.net

Wednesday 17 May 2006

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A cannabis plant extract provides pain relief for patients after major
surgery such as knee replacements, a study by Imperial College London
and the Medical Research Council has shown.

Details of a trial published today in Anesthesiology shows how effective
Cannador, a cannabis plant extract, is at managing post-operative pain.

Dr Anita Holdcroft, from Imperial College London, and lead researcher
said: "Pain after surgery continues to be a problem because many of the
commonly used drugs are either ineffective or have too many side
effects. These results show that cannabinoids are effective, and may
lead to the development of a wider range of drugs to manage
postoperative pain."

The researchers tested Cannador on 65 patients who had previously
undergone surgery. 11 patients received a 5mg dose, 30 received a 10mg
dose, and 24 received a 15mg dose. While all patients who received a 5mg
dose requested additional pain relief, only 15 of those who received the
10mg dose and 6 of those on the 15mg dose did so.

As the dose increased, patients reported decreasing pain intensity and
increasing side effects. Side effects included increasing nausea and
increased heart rate in some patients.

Professor Mervyn Maze from Imperial College London, and one of the
researchers, added: "We thought cannabis might be beneficial in helping
manage pain following surgery, as previous research indicated
cannabinoids help 'top up' the body's natural system for reducing pain
sensation. This research proves it can be effective, with minimal side
effects at low doses."

The study was conducted using patients from Chelsea and Westminster
Hospital, Charing Cross Hospital, Northwick Park Hospital, Kings College
Hospital, The Manor Walsall, The Whittington, St Bartholomew's,
University College London Hospital, West Middlesex and Ravenscourt Park
Hospital.

The study was funded by the Medical Research Council and the Westminster
Medical School Research Trust, which is administered by the Chelsea and
Westminster NHS Trust. The Cannador was donated by the Institute for
Clinical Research, Berlin.

http://www.imperial.ac.uk






 

 

 

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