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UK: Rheumatoid arthritis treatment from cannabis

BBC Online

Thursday 03 Aug 2000


Subject: UK: Rheumatoid arthritis treatment from cannabis

Source: BBC Online

Date: Thu, 3 Aug 2000



Scientists believe an ingredient of cannabis
greatly reduces the pain of rheumatoid arthritis
and could provide a cheaper alternative to
current anti-arthritis drugs.

Components of cannabis have long been known
to affect the immune system but now it seems
that one component, cannabidiol, can block
the progress of arthritis without any
intoxicating or psychoactive side effects.

Professor Marc Feldmann of the Kennedy
Institute of Rheumatology, who led the work,
believes that cannabidiol could become the
basis for a cheap anti-arthritis pill.

He told BBC Radio 4's Today programme: "It's a
constituent which has no properties on the
brain - it's not psychoactive, it can't give you
a high."

Rheumatoid-arthritis is the crippling
inflammation of the joints caused when the
bodies immune system turns on itself.

Rather than fighting infections, it attacks the
lining of the joints causing swelling and great
pain.

There are drugs available, but they are either
highly expensive, or produce severe
side-effects in many patients.

Human medical trials

The cannabis extract has only been tried in
mice so far, as described in the Proceedings of
the National Academy of Sciences.

However, Professor Feldmann says that this
drug is as effective in mice as a far more
expensive treatment that has to be taken by
injection.

The next stage would be to conduct small
scale human medical trials.

However, Professor Feldmann warned that it
could be up to five years before the drug might
be available, and that even finding sponsors
for the research was difficult, given the
associations with an illegal drug.

He said: "What we have found is that as soon
as you mention cannabis a lot of companies
get put right off and don't want to enter
discussions.

"There is certainly a hurdle to be crossed in
the development of this drug."

This research adds another potential use for
cannabis derived drugs.

Other cannabis compounds are effective
painkillers and research has suggested that
cannabis might help people with multiple
sclerosis.

 

 

 

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