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Cannabis Campaigners' Guide News Database result:
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UK: Chilled-out chemotherapy
Tudor P Toma The Scientist
Monday 06 Jan 2003 Cannabinoids can inhibit non-melanoma skin tumor growth in vivo. Cannabinoids - the active components of Cannabis sativa linnaeus (marijuana) - have growth-inhibiting effects on gliomas, but their potential for treating other tumors such as non-melanoma skin cancer, has been unclear. In the January 1 Journal of Clinical Investigation, Llanos Casanova and colleagues from Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas, Madrid, Spain, show that activation of cannabinoid receptors inhibit skin tumor growth and angiogenesis in vivo (Journal of Clinical Investigation, 111:43-50, January 1, 2003). Using nude mice, Casanova et al. injected the mixed CB1/CB2 agonist WIN-55,212-2 or the selective CB2 agonist JWH-133 into the epidermis adjacent to induced non-melanomic malignancies and observed a considerable inhibition in tumor growth. Cannabinoid-treated tumors showed an increased number of apoptotic cells, altered blood vessel morphology and decreased expression of proangiogenic factors (VEGF, placental growth factor, and angiopoietin 2). In addition, abrogation of EGF-R function was also observed in cannabinoid-treated tumors. "The present report, together with the implication of CB2- or CB2-like receptors in the control of peripheral pain and inflammation, opens the attractive possibility of finding cannabinoid-based therapeutic strategies for diseases of the skin and other tissues devoid of nondesired CB1-mediated psychotropic side effects," conclude the authors. Links for this article I. Galve-Roperh et al., "Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation," Nature Medicine, 6:313-319, 2000. [PubMed Abstract] B.L. Limmer, "Nonmelanoma skin cancer: today's epidemic," Texas Medicine, 97:56-58, 2001. [PubMed Abstract] M.L. Casanova et al., "Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors," Journal of Clinical Investigation, 111:43-50, January 1, 2003. http://www.jci.org/cgi/content/full/111/1/43?ijkey=1mHZx420NOAL6 Centro de Investigaciones Energeticas http://www.ciemat.es/eng/index.html ------------- See http://www.biomedcentral.com/news/20030106/04/ for live links
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