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UK: Cannabis trial on Parkinson's Disease

BBC Online

Thursday 17 Apr 2003

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Cannabis extract is to be trialled in a new South West study into
Parkinson's Disease.

The Peninsula Medical School is carrying out the study, which starts in
May and will involve 24 patients from Cornwall and Devon.

The study will be based at Derriford Hospital in Plymouth and will look
at whether the drug can help reduce the side effects of some existing
medication.

Participants will be using a cannabis derivative called Cannador, which
will be in capsule form.

Involuntary spasms

Parkinson's is one of the most common neurological diseases in older
people.

It is a progressive, degenerative, neurological condition for which
there is currently no cure. Sufferers find increasing difficulty in
moving their arms and legs.

They develop tremors and facial tics and gradually become more and more
immobile. It is usually kept under control by tablets.

Although the tablets are effective in the short-term, in the long-term
they can cause a condition known as dyskenesia - involuntary spasms of
the limbs.

Researchers at Derriford Hospital believe Cannador could ease this.

Neurology registrar Dr Camille Carroll said: "A short study carried out
in Manchester showed that a cannabis-type compound was helpful for
reducing these side effects.

"It showed the abnormal movements, which can be quite disabling, were
reduced by 30%.

"We're hoping we'll see a similar occurrence in this trial and this will
be maintained in the tie of taking the capsules."

During the 12-week trial, the effects of the cannabis oil will be
compared to a placebo.

If the study is successful, a case could be made for people with the
condition to be prescribed Cannador on a more regular basis.

Dr Carroll said: "Parkinson's can be very debilitating. There is a
spectrum and patients can range from being mildly affected to very
severely affected.

"In the worst cases, patients are very rigid and stiff and find every
movement difficult, so it's important that they have the treatment for
it.

"But it's unfortunate that the treatment can be just as debilitating as
the condition itself."

A report into a similar study carried out by the Peninsula Medical
School into the effect of cannabis on patients with multiple sclerosis
is due in the summer.


 

 

 

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