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UK: Patients to use cannabis in painkiller trial

The Times

Wednesday 20 Aug 2003

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Hospital patients scheduled to undergo surgery were being asked to take
part in trials to find out if cannabis can provide pain relief after an
operation.

The trials were being carried out at hospitals throughout the UK in the
hope of measuring the effects of cannabis plant extract against other pain
relieving drugs.

Doctors carrying out the study for the Medical Research Council were hoping
to recruit 400 surgical patients to take part.

Each patient was being randomly assigned to one of four oral pain relieving
treatments containing either standardised cannabis extract,
tetrahydrocannabinol (an active ingredient in cannabis), a standard pain
relieving drug, or a placebo.

The pain relief and side effects were then being assessed over a six-hour
period with patients being asked to respond to questions about their pain
and feelings.

Dr Anita Holdcroft, from Imperial College London, who is leading the
UKP500,000 trial, said anecdotal evidence suggesting cannabis could provide
effective pain relief for a variety of debilitating conditions needed to be
assessed scientifically.

"My patients and clinicians want an answer to the question of whether
cannabis is effective at relieving pain.

"We need to assess the scientific merits of some of the anecdotal evidence
and we need to do this in the same way as any other experimental pain
treatment.

"This is a proper study in a clinical setting where patients can be
routinely monitored, using an oral capsule containing a prescribed dose,"
she said.

She added that if oral cannabis plant extract was found to be effective and
without adverse side effects, it could provide another pain relief option
to doctors and patients.

Cannabis DrugScope, a charity that aims to advise and inform on
drug-related policy, welcomed the trials.Frank Warburton, director of
DrugScope, said: "The therapeutic benefits of cannabis have been well-known
for some time.

"We welcome this trial which appears to be a sensible and rational
exploration of these benefits, and look forward to seeing the results of
the evaluation."

A spokesman for the British Medical Association also welcomed the study.

He said: "BMA research has shown that although cannabis itself is
unsuitable for medical use, some cannabis-based medicines have the
potential to relieve pain.

"There has long been a need for more research into the effectiveness of
cannabinoids for therapeutic purposes and this is a welcome development."


The MRC confirmed that the hospitals currently signed up to take part in
the trial are:

Chelsea and Westminster, London

Charing Cross, London

Hammersmith, London

Ravenscourt Park, London

Barts and the Royal London, London

The Middlesex UCLH, London

The Manor, Walsall, West Midlands

Ealing Hospital, London

Hillingdon Hospital, London

West Middlesex, Middlesex

The Whittington, London

Royal United Hospital, Bath

St John's Hospital, Livingston, Lothian

Royal Victoria Hospital, Belfast

City Hospital, Nottingham

Queen Victoria Hospital, East Grinstead, West Sussex

Royal Devon & Exeter Hospital

York District Hospital

Southampton General

Derriford Hospital, Plymouth

Wexham Hospital, Slough, Berkshire

Wrexham Maelor, North Wales

Glasgow Gartnavel

Whipps Cross, London

Luton & Dunstable Hospital, Bedfordshire

The Lister Hospital, Stevenage, Hertfordshire

Stirling Royal Infirmary,

Falkirk & District Royal Infirmary

Victoria Infirmary, Glasgow

Blackpool Victoria Hospital

Princess Alexandra, Harlow. Essex

Royal Liverpool University Hospital

Southmead Hospital, Bristol

James Cook University Hospital, Middlesbrough

Ipswich Hospital, Suffolk

 

 

 

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