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UK information & news archive

Medical cannabis research & archive

Research references, historical press coverage, treatment topics and related source material.

Medical references ? Browse the site index
Cannabis Campaigners Guide UK CCGUIDE · Cannabis Campaigners Guide
Selected reading

Press articles

GreenMedInfoMarijuana Compound Found Superior To Drugs For Alzheimer'sOpen article ? VideoThe surprising story of medical marijuana and pediatric epilepsyOpen article ? The GuardianBetter Night Vision through CannabisOpen article ?
Research references

Cancer studies by country

Archive note: these links are historical research references collected by CCGUIDE. Their inclusion is not a medical recommendation or a statement that every study supports the same conclusion.

Germany

Pharmacokinetics and pharmacodynamics of cannabinoidsCannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptorCannabinoid receptors in human astroglial tumorsUp-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cellsAntitumorigenic effects of cannabinoids beyond apoptosisR(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathway

Israel

HU-331, a novel cannabinoid-based anticancer topoisomerase II inhibitorAn endogenous cannabinoid (2-AG) is neuroprotective after brain injuryGamma-irradiation enhances apoptosis induced by cannabidiol, a non-psychotropic cannabinoid, in cultured HL-60 myeloblastic leukemia cellsA cannabinoid quinone inhibits angiogenesis by targeting vascular endothelial cellsCannabinoids in health and diseaseCannabinoids and cancerDelta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells

Italy

Endocannabinoids in the immune system and cancerA metabolically stable analogue of anandamide, Met-F-AEA, inhibits human thyroid carcinoma cell lines by activation of apoptosisPlant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cellsAnandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptorsThe endogenous cannabinoid anandamide inhibits human breast cancer cell proliferationCannabinoids as potential new therapy for the treatment of gliomasThe non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cellsEndocannabinoids as emerging suppressors of angiogenesis and tumor invasion (review)Apoptosis induced in HepG2 cells by the synthetic cannabinoid WIN: involvement of the transcription factor PPARgamma[The endocannabinoid system as a target for the development of new drugs for cancer therapy]Cannabinoids in intestinal inflammation and cancerAntitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinomaThe CB1/CB2 receptor agonist WIN-55,212-2 reduces viability of human Kaposi's sarcoma cells in vitroCannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor-independent mechanismThe endocannabinoid anandamide neither impairs in vitro T-cell function nor induces regulatory T-cell generationAntitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell linesEstrogenic induction of cannabinoid CB1 receptor in human colon cancer cell linesEndocannabinoids and fatty acid amides in cancer, inflammation and related disorders

Spain

De novo-synthesized ceramide is involved in cannabinoid-induced apoptosisDown-regulation of tissue inhibitor of metalloproteinases-1 in gliomas: a new marker of cannabinoid antitumoral activity?Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesisCannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cellsJunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cellsCannabinoid receptors as novel targets for the treatment of melanomaAnti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activationEndocannabinoids: a new family of lipid mediators involved in the regulation of neural cell developmentCannabinoids and ceramide: two lipids acting hand-by-handp38 MAPK is involved in CB2 receptor-induced apoptosis of human leukaemia cellsThe CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathwayThe stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cellsControl of the cell survival/death decision by cannabinoidsInhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)-Methanandamide and JWH-015: involvement of CB2Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptorsOpposite changes in cannabinoid CB1 and CB2 receptor expression in human gliomasDelta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulationCannabinoids and gliomasCannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genesEffects on cell viabilityInvolvement of cannabinoids in cellular proliferationHypothesis: cannabinoid therapy for the treatment of gliomas?Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B pathwayCannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expressionDelta9-tetrahydrocannabinol induces apoptosis in C6 glioma cellsDelta9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanismCannabinoids and cell fateAmphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis

Sweden

Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolismCannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphomaCannabinoid receptor-mediated apoptosis induced by R(+)-methanandamide and Win55,212-2 is associated with ceramide accumulation and p38 activation in mantle cell lymphomaExpression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: growth inhibition by receptor activation

United Kingdom

Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathwayThe cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cellsCannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell deathHigh concentrations of cannabinoids activate apoptosis in human U373MG glioma cellsCannabinoid receptor systems: therapeutic targets for tumour intervention

United States Of America

Cannabinoids as novel anti-inflammatory drugsCannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cellsIn vivo effects of cannabinoids on macromolecular biosynthesis in Lewis lung carcinomasCannabinoid receptor as a novel target for the treatment of prostate cancerTargeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic diseaseCannabinoids for cancer treatment: progress and promiseSynthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancerCannabinoid-induced apoptosis in immune cells as a pathway to immunosuppressionDelta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondriaDelta(9)-tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivoCannabinoids and the immune systemCannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survivalCannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expressionThe expression level of CB1 and CB2 receptors determines their efficacy at inducing apoptosis in astrocytomasTargeting cannabinoid receptors to treat leukemia: role of cross-talk between extrinsic and intrinsic pathways in Delta9-tetrahydrocannabinol (THC)-induced apoptosis of Jurkat cells
Original CCGUIDE material

Medical cannabis archive

The wording, quotations and claims below are preserved from the historical page and should be read in the context of their original dates and sources.

Between 1840 and 1900 over 1000 major medical articles recommending cannabis as a therapeutic agent were published.

It is still puzzling that no serious modern survey of the therapeutic value in cannabis has been conducted. This is because it is illegal, and may well be due to pressures from the pharmaceutical and drug companies who fear loss of profits if cannabis is accepted medicinally. Just imagine all those people growing their own remedy!

Historical treatment topics

Selected press reports on medical uses

  • This is the list of states with medical marijuana to the best of my knowledge - California, Oregon, Washington, Alaska, Arizona, and Nevada. Colorado and the District of Columbia both voted in favour of it but were both denied by the government. (November 1998)

Canadian Judge Rules Medical Marijuana is allowed : Thursday, 11 December 1997: Ottawa Citizen

At the 10th International Conference on Drug Policy, 1996, USA John P Morgan MD, Professor of Pharmacology, City University of New York Medical School, said of Marinol, the synthetic THC marketed in the States, "In a recent study, the scientists gave patients 20 mg of Marinol by mouth to see if it increased their appetite. Not only could they not detect much appetite-increasing effect, but also they learned the interesting fact that, in one-third of people who take Marinol by mouth, you have no blood levels at all. The drug is so poorly bio-available it's surprising that it got onto the market. There may well be some reason to believe that there are individuals in our government who are interested in getting Marinol on the market to diminish the pressure for marijuana smokers."

Testimony of Lester Grinspoon, M.D. Associate Professor of Psychiatry, Harvard Medical School before the Crime Subcommittee of the Judiciary Committee, U.S. House of Representatives, Washington, D.C., October 1, 1997

One of the best effects Marijuana can have in any terminal illness is to produce a degree of euphoria which boosts morale in a depressing situation.....Dr. Anthony Henman

I'm quite impressed by what's happened to (MS) patients who have used it...Dr. James Malone-Lee, consultant St. Pancras Hospital, London

Marijuana is beneficial to many patients ..Jocelyn Elders, USA Surgeon General

For more information on the medical uses of marijuana / cannabis check out

The Flow medical page

SEE ALSO: Medical references

Medical cannabis press archive

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